Types of Hemophilia and other bleeding disorders
Hempophilia A or classic hemophilia: A person with this type of hemophilia has low levels of or is completely missing factor 8 (Also called FVIII or factor VIII deficiency) 80% of people with hemophilia have Type A Hemophilia. Factor VIII deficiency usually manifests in males.
In about 30% of cases, there is no family history of this bleeding disorder and it is just a spontaneous genetic mutation. About 1 in 5,000 males born in the United States has hemophilia. All economic groups and races are affected equally.
Hemophilia B: This person has low levels of or is completely missing factor 9 (Also called FIX or factor IX deficiency) 20% of people with hemophilia have Type B Hemophilia. Factor IX deficiency usually manifests in males.
Hemophilia B was originally called "Christmas Disease" when it was first diagnosed in 1952. About 30% of cases of Hemophilia B are caused by spontaneous genetic mutation.
Hemophilia B is much less common than Hemophilia A. It occurs in about 1 in 25,000 male births, and affects about 3,300 individuals in the United States. All races and economic groups are affected equally.
Hemophilia C: This person has low levels of or is missing completely factor 11 (Also called FXI or factor XI deficiency) Hemophilia C is 10 times more rare than type A. Factor XI deficiency is different because it can show up in both males and females.
Von Willebrands Disease: A bleeding disease similar to Hemophilia that affects both males and females equally. It is caused by a deficiency of a blood clotting protein called Von Willebrand factor. Von Willebrand factor circulates attached to factor VIII and is necessary to form a clot.
Von Willebrands Disease occurs in 1 - 2% of the population. It is a genetic bleeding disorder that can be inherited from either parent, unlike hemophilia. It affects males and females equally.
Von Willebrand Disease can be difficult to diagnose. A blood clotting test can be performed to measure the amount and characteristics of von Willebrand Factor. Because levels can vary, sometimes a blood clotting test may need to be repeated. A person who might have von Willebrand Disease should be referred to a hematologist who specializes in diagnosing and treating bleeding disorders.
Three levels of Hemophilia severity
Severe 0% - 1% factor level. About 80% of hemophilia sufferers are considered severe. Severe hemophilia sufferers will have excessive bleeding after injuries, surgery and can also have spontaneous bleeding episodes. They can also have joint bleeding and prolonged bleeding into the muscles, sometime times without the person's knowledge. Joint bleeding can cause joint deterioration and arthritis down the road.
Moderate 1% - 5% factor level. About 10% of hemophilia sufferers are considered moderate. Moderate sufferers may have spontaneous bleeding episodes and will probably have prolonged bleeding after injuries.
Mild 5% - 50% factor level. About 10% of hemophilia sufferers are considered mild. These people have prolonged bleeding after a serious injury, trauma or surgery. In many cases, mild hemophilia is not discovered until there is excessive bleeding after a surgery or injury. In fact, it may not even be discovered until adulthood.
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